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USC-OGP 2-DE database
Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database
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Searching in 'USC-OGP 2-DE database' for entry
matching:
PRPS1_HUMAN
USC-OGP 2-DE database
:
PRPS1_HUMAN
PRPS1_HUMAN
General information about the entry
View entry in simple text format
Entry name
PRPS1_HUMAN
Primary accession number
P60891
integrated into USC-OGP 2-DE database on
January 17, 2017 (release 1)
2D Annotations were last modified on
January 17, 2017 (version 1)
General Annotations were last modified on
April 5, 2017 (version 2)
Name and origin of the protein
Description
RecName: Full=Ribose-phosphate pyrophosphokinase 1; EC=2.7.6.1; AltName: Full=PPRibP; AltName: Full=Phosphoribosyl pyrophosphate synthase I; Short=PRS-I;.
Gene name
Name=PRPS1
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein
UVEAL_MELANOMA_3-10
{UVEAL MELANOMA 3-10}
Homo sapiens (Human)
map experimental info
UVEAL_MELANOMA_3-10
MAP LOCATIONS:
SPOT OGP-1234
:
pI=6.98; Mw=33419
Cross-references
UniProtKB/Swiss-Prot
P60891; PRPS1_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
0.0
Entry name
PRPS1_HUMAN
Primary accession number
P60891
Secondary accession number(s)
B1ALA8 B2R6T7 B4DNL6 D3DUX6 P09329
Sequence was last modified on
January 23, 2007 (version 2)
Annotations were last modified on
March 15, 2017 (version 148)
Name and origin of the protein
Description
RecName: Full=Ribose-phosphate pyrophosphokinase 1; EC=2.7.6.1; AltName: Full=PPRibP; AltName: Full=Phosphoribosyl pyrophosphate synthase I; Short=PRS-I;
Gene name
Name=PRPS1
Encoded on
Name=PRPS1
Keywords
3D-structure
;
Alternative splicing
;
ATP-binding
;
Charcot-Marie-Tooth disease
;
Complete proteome
;
Deafness
;
Direct protein sequencing
;
Disease mutation
;
Gout
;
Kinase
;
Magnesium
;
Mental retardation
;
Metal-binding
;
Neurodegeneration
;
Neuropathy
;
Non-syndromic deafness
;
Nucleotide biosynthesis
;
Nucleotide-binding
;
Polymorphism
;
Reference proteome
;
Retinitis pigmentosa
;
Transferase
.
Copyright
Copyrighted by the UniProt Consortium, see
http://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
X15331; CAA33386.1
; -; mRNA
EMBL
D00860; BAA00733.1
; -; mRNA
EMBL
AK297968; BAG60278.1
; -; mRNA
EMBL
AK312706; BAG35584.1
; -; mRNA
EMBL
AL137787; CAI42173.1
; -; Genomic_DNA
EMBL
AL772400; CAI42173.1
; JOINED; Genomic_DNA
EMBL
AL772400; CAI41098.1
; -; Genomic_DNA
EMBL
AL137787; CAI41098.1
; JOINED; Genomic_DNA
EMBL
CH471120; EAX02709.1
; -; Genomic_DNA
EMBL
CH471120; EAX02710.1
; -; Genomic_DNA
EMBL
CH471120; EAX02711.1
; -; Genomic_DNA
EMBL
BC001605; AAH01605.1
; -; mRNA
CCDS
CCDS14529.1; -. [P60891-1]
; .
PIR
JX0159; KIHUR1
; .
RefSeq
NP_001191331.1; NM_001204402.1
; .
RefSeq
NP_002755.1; NM_002764.3. [P60891-1]
; .
UniGene
Hs.56; -
; .
PDB
2H06; X-ray
; 2.20 A; A/B=1-318
PDB
2H07; X-ray
; 2.20 A; A/B=1-318
PDB
2H08; X-ray
; 2.50 A; A/B=1-318
PDB
2HCR; X-ray
; 2.20 A; A/B=1-318
PDB
3EFH; X-ray
; 2.60 A; A/B=1-318
PDB
3S5J; X-ray
; 2.02 A; A/B=1-318
PDB
4F8E; X-ray
; 2.27 A; A/B=1-318
PDB
4LYG; X-ray
; 3.00 A; A/B=1-318
PDB
4LZN; X-ray
; 2.14 A; A/B=1-318
PDB
4LZO; X-ray
; 3.31 A; A/B=1-318
PDB
4M0P; X-ray
; 2.11 A; A/B=1-318
PDB
4M0U; X-ray
; 2.74 A; A/B=1-318
PDBsum
2H06; -
; .
PDBsum
2H07; -
; .
PDBsum
2H08; -
; .
PDBsum
2HCR; -
; .
PDBsum
3EFH; -
; .
PDBsum
3S5J; -
; .
PDBsum
4F8E; -
; .
PDBsum
4LYG; -
; .
PDBsum
4LZN; -
; .
PDBsum
4LZO; -
; .
PDBsum
4M0P; -
; .
PDBsum
4M0U; -
; .
ProteinModelPortal
P60891; -
; .
SMR
P60891; -
; .
BioGrid
111615; 49
; .
DIP
DIP-61999N; -
; .
IntAct
P60891; 17
; .
STRING
9606.ENSP00000361512; -
; .
BindingDB
P60891; -
; .
ChEMBL
CHEMBL2638; -
; .
iPTMnet
P60891; -
; .
PhosphoSitePlus
P60891; -
; .
SwissPalm
P60891; -
; .
BioMuta
PRPS1; -
; .
DMDM
46397477; -
; .
UCD-2DPAGE
P60891; -
; .
EPD
P60891; -
; .
MaxQB
P60891; -
; .
PaxDb
P60891; -
; .
PeptideAtlas
P60891; -
; .
PRIDE
P60891; -
; .
DNASU
5631; -
; .
Ensembl
ENST00000372435; ENSP00000361512
; ENSG00000147224. [P60891-1]; .
GeneID
5631; -
; .
KEGG
hsa:5631; -
; .
UCSC
uc004ene.5; human. [P60891-1]
; .
CTD
5631; -
; .
DisGeNET
5631; -
; .
GeneCards
PRPS1; -
; .
GeneReviews
PRPS1; -
; .
HGNC
HGNC:9462; PRPS1
; .
MalaCards
PRPS1; -
; .
MIM
300661; phenotype
; .
MIM
301835; phenotype
; .
MIM
304500; phenotype
; .
MIM
311070; phenotype
; .
MIM
311850; gene
; .
neXtProt
NX_P60891; -
; .
OpenTargets
ENSG00000147224; -
; .
Orphanet
1187; Lethal ataxia with deafness and optic atrophy
; .
Orphanet
411536; Mild phosphoribosylpyrophosphate synthetase superactivity
; .
Orphanet
411543; Severe phosphoribosylpyrophosphate synthetase superactivity
; .
Orphanet
99014; X-linked Charcot-Marie-Tooth disease type 5
; .
Orphanet
90625; X-linked non-syndromic sensorineural deafness type DFN
; .
PharmGKB
PA33817; -
; .
eggNOG
KOG1448; Eukaryota
; .
eggNOG
COG0462; LUCA
; .
GeneTree
ENSGT00550000074583; -
; .
HOGENOM
HOG000210451; -
; .
HOVERGEN
HBG001520; -
; .
InParanoid
P60891; -
; .
KO
K00948; -
; .
OMA
DGEIMVE; -
; .
OrthoDB
EOG091G0ZG8; -
; .
PhylomeDB
P60891; -
; .
TreeFam
TF106366; -
; .
BioCyc
MetaCyc:HS07410-MONOMER; -
; .
BRENDA
2.7.6.1; 2681
; .
Reactome
R-HSA-73843; 5-Phosphoribose 1-diphosphate biosynthesis
; .
UniPathway
UPA00087; UER00172
; .
ChiTaRS
PRPS1; human
; .
EvolutionaryTrace
P60891; -
; .
GenomeRNAi
5631; -
; .
PRO
PR:P60891; -
; .
Proteomes
UP000005640; Chromosome X
; .
Bgee
ENSG00000147224; -
; .
CleanEx
HS_PRPS1; -
; .
ExpressionAtlas
P60891; baseline and differential
; .
Genevisible
P60891; HS
; .
GO
GO:0005829; C:cytosol
; TAS:Reactome; .
GO
GO:0043234; C:protein complex
; IEA:Ensembl; .
GO
GO:0002189; C:ribose phosphate diphosphokinase complex
; IEA:Ensembl; .
GO
GO:0043531; F:ADP binding
; IEA:Ensembl; .
GO
GO:0016208; F:AMP binding
; IEA:Ensembl; .
GO
GO:0005524; F:ATP binding
; IDA:UniProtKB; .
GO
GO:0030246; F:carbohydrate binding
; IEA:Ensembl; .
GO
GO:0019003; F:GDP binding
; IEA:Ensembl; .
GO
GO:0042802; F:identical protein binding
; IPI:IntAct; .
GO
GO:0016301; F:kinase activity
; IEA:UniProtKB-KW; .
GO
GO:0000287; F:magnesium ion binding
; IEA:Ensembl; .
GO
GO:0042803; F:protein homodimerization activity
; IPI:UniProtKB; .
GO
GO:0004749; F:ribose phosphate diphosphokinase activity
; IDA:UniProtKB; .
GO
GO:0006015; P:5-phosphoribose 1-diphosphate biosynthetic process
; TAS:Reactome; .
GO
GO:0006167; P:AMP biosynthetic process
; IEA:Ensembl; .
GO
GO:0031100; P:animal organ regeneration
; IEA:Ensembl; .
GO
GO:0046101; P:hypoxanthine biosynthetic process
; IMP:UniProtKB; .
GO
GO:0007399; P:nervous system development
; IMP:UniProtKB; .
GO
GO:0006144; P:purine nucleobase metabolic process
; IMP:UniProtKB; .
GO
GO:0006164; P:purine nucleotide biosynthetic process
; IMP:UniProtKB; .
GO
GO:0006221; P:pyrimidine nucleotide biosynthetic process
; NAS:UniProtKB; .
GO
GO:0034418; P:urate biosynthetic process
; IMP:UniProtKB; .
CDD
cd06223; PRTases_typeI
; 1; .
Gene3D
3.40.50.2020; -
; 2; .
HAMAP
MF_00583_B; RibP_PPkinase_B
; 1; .
InterPro
IPR000842; PRib_PP_synth_CS
; .
InterPro
IPR029099; Pribosyltran_N
; .
InterPro
IPR000836; PRibTrfase_dom
; .
InterPro
IPR029057; PRTase-like
; .
InterPro
IPR005946; Rib-P_diPkinase
; .
Pfam
PF14572; Pribosyl_synth
; 1; .
Pfam
PF13793; Pribosyltran_N
; 1; .
SUPFAM
SSF53271; SSF53271
; 1; .
TIGRFAMs
TIGR01251; ribP_PPkin
; 1; .
PROSITE
PS00114; PRPP_SYNTHASE
; 1; .
Gateways to other related servers
The World-2DPAGE Constellation
- Entry point to the world-wide 2-DPAGE resources.
World-2DPAGE Repository
- A public repository for gel-based proteomics data linked to protein identification published in the literature.
World-2DPAGE Portal
- A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
SWISS-2DPAGE
- The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
ExPASy
- The resources web server of the
Swiss Institute of Bioinformatics
Database constructed and maintained by
Angel Garcia
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server
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